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Moreover, in H4IIE cells, a rat hepatoma cell line, that were stably transfected with the cDNA for the 2-oxoglutarate carrier, exhibited increased uptake of GSH and 2-oxoglutarate and were protected from cytotoxicity induced by hydrogen peroxide, methyl vinyl ketone, or cisplatin, demonstrating the protective function of increased mitochondrial GSH transport and mGSH levels in the liver (153)
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13 , for instance, highlighted the complexity of neuronal responses and the possibility that subtle molecular perturbations might not translate immediately into functional deficits